Quorum-sensing (QS) signalling systems of pathogens are central regulators for the expression of virulence factors and represent highly attractive targets for the development of novel therapeutics. In Pseudomonas aeruginosa, QS systems are also involved in elevated antibiotic tolerance of biofilms as well as elevated tolerance to the activity of the innate immune system. Quorum-sensing inhibitors as anti-pathogenic drugs. Int. J. Med. Microbiol. 296(2), 149–161 (2006).Crossref, Medline, CAS, • Summary of new antibacterial drugs and alternative approaches to combat bacterial infections.Crossref, Medline, Quorum sensing inhibitors (QSIs) are being used widely as a promising alternative to antibiotics and drawing attention as potential pollutants. However, the assessment methods of the toxicities of... Quorum Sensing Inhibitors as Pathoblockers for Pseudomonas The discovery of anti-pathogenic compounds necessitates a profound understanding of the respective pathogenic mechanisms and modern medicinal chemistry strategies in order et al (2007) Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request. Quorum-sensing (QS) signalling systems of pathogens are central regulators for the expression of virulence factors and represent highly attractive targets for the development of novel therapeutics. In Pseudomonas aeruginosa, QS systems are also involved in elevated antibiotic tolerance of biofilms as well as elevated tolerance to the activity of the innate immune system. This research has opened the door to the development of anti-pathogenic drugs. One approach to suppress bacterial virulence is via quorum sensing inhibition. Quorum sensing is a mechanism that bacteria use to monitor and respond to changes in environmental conditions, in a population density dependent manner 2, 3. Quorum-sensing inhibitors as anti-pathogenic drugs. Research output: Contribution to journal › Journal article. Givskov, Michael; Quorum-sensing (QS) signalling systems of pathogens are central regulators for the expression of virulence factors and represent highly attractive targets for the development of novel therapeutics. Quorum-sensing (QS) signalling systems of pathogens are central regulators for the expression of virulence factors and represent highly attractive targets for the development of novel therapeutics. In Pseudomonas aeruginosa, QS systems are also involved in elevated antibiotic tolerance of biofilms as well as elevated tolerance to the activity of the innate immune system. Citation: Cotar AI (2013) Quorum Sensing Inhibitors as Anti-Pathogenic Drugs in the Fight Against Pseudomonas aeruginosa Infections. Clin Microbial 2: e11 1. doi: 10.4172/2327-5073.1000e11 1
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